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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Overexpression of the proneural transcription factor ASCL1 in chronic lymphocytic leukemia with a t(12;14)(q23.2;q32.3)

Fig. 2

Translocation breakpoints and derivative chromosome composition. Horizontal gray arrows indicate the transcriptional direction of the depicted genes. Vertical black arrows indicate breakpoints (BP). a Breakpoint region on chromosome 12. The breakpoint took place 86.5 kb distal of the ASCL1 gene. b The IGH locus on chromosome 14. The breakpoint took place within the pentameric repeat region of Switch μ. Dots indicate the IGH enhancer elements. c Composition of der(12) and sequence around the breakpoint. The enhancer element is part of the translocated IGH sequence and is juxtaposed to ASCL1. d der(14) and breakpoint sequence. The C12orf42 gene is translocated to chromosome 14

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