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Table 1 Univariate logistic regression results for clinical parameters considering the five PTEN deletion subtypes. PTEN intact was set as a baseline in the model. Large Interstitial deletions are reliable predictors of high Gleason scores, extraprostatic extension, and metastasis. The model represents the occurrence of each event analyzed. High Gleason score was obtained through dichotomization: Gleason scores ≤7 were considered as low, and ≥8 were considered as high. *Significant P-value < 0.05

From: Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Clinical Feature

P-value

Odds Ratio

95% C.I.

Lower

Upper

High Gleason Score

    

 Small Interstitial

0.26

1.893

0.624

5.744

 Large Interstitial

0.009*

2.386

1.245

4.572

 Large Proximal

0.91

0.946

0.364

2.460

 Large Terminal

0.45

1.298

0.651

2.587

 Extensive

0.057

8.112

0.938

70.137

PTEN Intact

0.00

0.616

.

.

Extraprostatic Extension

 Small Interstitial

0.16

2.524

0.683

9.322

 Large Interstitial

0.01*

2.423

1.157

5.075

 Large Proximal

0.01*

6.436

1.466

28.260

 Large Terminal

0.31

1.451

0.701

3.005

 Extensive

0.99

.

0.000

.

PTEN Intact

0.00

1.321

.

.

Metastasis

 Small Interstitial

.

.

.

.

 Large Interstitial

0.01*

7.135

1.540

33.044

 Large Proximal

.

.

.

.

 Large Terminal

0.38

2.650

0.288

24.364

 Extensive

.

.

.

.

PTEN Intact

0.00

0.011

.

.

Seminal Vesicle Invasion

    

 Small Interstitial

0.03*

3.431

1.119

10.412

 Large Interstitial

0.001*

2.660

1.389

5.091

 Large Proximal

0.04*

2.633

1.038

6.677

 Large Terminal

0.98

1.013

0.458

2.239

 Extensive

0.19

2.926

0.580

14.744

PTEN Intact

0.00

0.342

.

.