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Table 1 Univariate logistic regression results for clinical parameters considering the five PTEN deletion subtypes. PTEN intact was set as a baseline in the model. Large Interstitial deletions are reliable predictors of high Gleason scores, extraprostatic extension, and metastasis. The model represents the occurrence of each event analyzed. High Gleason score was obtained through dichotomization: Gleason scores ≤7 were considered as low, and ≥8 were considered as high. *Significant P-value < 0.05

From: Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Clinical Feature P-value Odds Ratio 95% C.I.
Lower Upper
High Gleason Score     
 Small Interstitial 0.26 1.893 0.624 5.744
 Large Interstitial 0.009* 2.386 1.245 4.572
 Large Proximal 0.91 0.946 0.364 2.460
 Large Terminal 0.45 1.298 0.651 2.587
 Extensive 0.057 8.112 0.938 70.137
PTEN Intact 0.00 0.616 . .
Extraprostatic Extension
 Small Interstitial 0.16 2.524 0.683 9.322
 Large Interstitial 0.01* 2.423 1.157 5.075
 Large Proximal 0.01* 6.436 1.466 28.260
 Large Terminal 0.31 1.451 0.701 3.005
 Extensive 0.99 . 0.000 .
PTEN Intact 0.00 1.321 . .
Metastasis
 Small Interstitial . . . .
 Large Interstitial 0.01* 7.135 1.540 33.044
 Large Proximal . . . .
 Large Terminal 0.38 2.650 0.288 24.364
 Extensive . . . .
PTEN Intact 0.00 0.011 . .
Seminal Vesicle Invasion     
 Small Interstitial 0.03* 3.431 1.119 10.412
 Large Interstitial 0.001* 2.660 1.389 5.091
 Large Proximal 0.04* 2.633 1.038 6.677
 Large Terminal 0.98 1.013 0.458 2.239
 Extensive 0.19 2.926 0.580 14.744
PTEN Intact 0.00 0.342 . .