Fig. 3

Variation of mutation, tumor heterogeneity, aneuploidy, and genomic instability in PTEN deletion subtypes in prostate cancer. The boxplots show a - the total number of mutations, b – aneuploidy, as percentage of genome altered, c - Mutant-Allele Tumor Heterogeneity (MATH) score, and d - total number of SCNAs. The different deletion subtypes show increased heterogeneity for all evaluated parameters. PTEN intact tumors also show increased heterogeneity, with a significant number of outliers. SCNA – somatic copy number alteration, SI – Small Interstitial, LI – Large Interstitial, LP – Large Proximal, LT – Large Terminal, E – Extensive