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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Fig. 1

Chromosome 10 characterization and LCR mapping of the different PTEN deletion subtypes in prostate cancer. The panel below the schematic map of chromosome 10 demonstrates the different deletion subtypes and their frequency for each group. The genome is displayed horizontally, and the frequency of somatic copy number alterations (SCNA) at any given location are displayed on the y-axis. Red, pink and blue indicate the frequencies as a percentage of hemizygous deletions, homozygous deletions, and gains, respectively. The three thin continuous vertical lines show the precise location of the genes BMPR1A, PTEN, and FAS genes. The number of deletions for each subtype is shown in parentheses. The tumors that have PTEN intact are also shown. The panel above shows the intrachromosomal LCR regions along chromosome 10 with related regions of homology linked by thin blue lines. The five grey vertical dashed lines identify clusters of LCRs that map to the vicinity of PTEN deletion breakpoints defined by copy number transitions. Many deletions appear to originate at the small LCR cluster in between PTEN and BMPR1A. Mapping was performed using data from the Segmental Duplication database (http://humanparalogy.gs.washington.edu) for sequences with more or equal to 5Kb and showing equal or more similarity in 90% of the duplicated sequence

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