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Fig. 5 | Molecular Cytogenetics

Fig. 5

From: Noninvasive prenatal diagnosis of fetal aneuploidy by circulating fetal nucleated red blood cells and extravillous trophoblasts using silicon-based nanostructured microfluidics

Fig. 5

Array comparative genomic hybridization (aCGH) and next generation sequencing (NGS) for the same whole genome amplification (WGA) products of captured fnRBC from 5 pregnant women. WGA product from Promega male DNA (Promega, Wisconsin, USA) was used as reference. The aCGH were performed with GenetiSure Pre-Screen Array Kit 8x60K (Agilent Technologies, CA, USA) on a G4900DA SureScan microarray scanner (Agilent Technologies). NGS was performed using Ion PGM Hi-Q Sequencing Kit with Ion 316 chip (Thermo Fisher Scientific, California, USA) on the Ion Torrent PGM Instrument (Thermo Fisher Scientific) platform. Aneuploidy chromosomes are indicated by arrows. Aneuploidy chromosomes are indicated by arrows. The results of aCGH are comparable with that of NGS

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