Fig. 1
From: Unique amplification of BCR-ABL1 gene fusion in a case of T-cell acute lymphoblastic leukemia
Cytogenetic analysis on bone marrow sample of the patient at diagnosis. a Partial karyogram showing chromosomes 9 and 22 including a normal chromosome 9, a derivative chromosome 9 (green arrow), a normal chromosome 22, and an isodicentric Philadelphia chromosome 22 (red arrow). b Ideograms of G-banding patterns for chromosomes 9 and 22 showing the formation of the isodicentric Philadelphia chromosome 22 with hsr. c Metaphase-FISH using dual-color dual-fusion BCR-ABL1 probes showing multiple copies of BCR-ABL1 fusions in the isodicentric Philadelphia chromosome 22 (red arrow). d Ideograms of FISH signals for BCR and ABL1 genes showing their distributions. e Interphase-FISH using dual-color dual-fusion BCR-ABL1 probes showing multiple copies of BCR-ABL1 fusion signals in 41% of interphase nucleus analyzed (red arrows)