Fig. 3

Cytogenetic studies and scheme of meiotic quadrivalent of t(4;19)(p15.32;p13.3). a Partial karyotype of t(4;19)(p15.32;p13.3) carrier (V;1) studied by GTG (upper line) and RBG (lower line) techniques with indication of the breakpoint position on chromosomes and ideograms. b FISH studies on metaphase chromosomes of t(4;19)(p15.32;p13.3) carrier (V;1), left: WHSCR probe (red) and control probe 4qter (green): one red hybridization signal seen on normal chromosome 4 and second one on der(19)t(4;19)(p15.32;p13.3) indicating the breakpoint position on der(4) proximally to WHSCR; two green signals are seen: one on normal chromosome 4 and second one on der(4)t(4;19)(p15.32;p13.3); right: 19pter subtelomere specific probe (red): one hybridization signal is seen on normal chromosome 19 and second one on der(4)t(4;19)(p15.32;p13.3) indicating breakpoint position on der(19) proximally to 19pter subtelomere specific probe. c Scheme of meiotic quadrivalent of t(4;19)(p15.32;p13.3) carrier with possible forms of imbalance following meiotic disjunction and segregation. d Analysis of survival data in progeny till birth with possible forms of imbalance produced following meiosis in a t(4;19)(p15.32;p13.3) carrier