Combination of t(4;14), del(17p13), del(1p32) and 1q21 gain FISH probes identifies clonal heterogeneity and enhances the detection of adverse cytogenetic profiles in 233 newly diagnosed multiple myeloma

Table 1 Distribution of FISH abnormalities

Cytogenetic abnormalities [number of patients with available data]	n [%]
1p32/CDKN2C-FAF1 – 1q21/CKS1B probe [n = 230]
1q21 gain = 3 copies	87 [37.8]
1q21 gain >3 copies	42 [18.3]
1p32 monoallelic deletion	19 [8.3]
1p32 biallelic deletion	1 [0.4]
monosomy 1	4 [1.7]
trisomy 1	7 [3.0]
TP53/CEP17 probe [n = 233]
17p13 monoallelic deletion	35 [15.0]
monosomy 17	11 [4.7]
trisomy 17	32 [13.7]
trisomy 17 with one TP53 loss	6 [2.6]
IGH break-apart and t(4;14)(p16;q32) - IGH/FGFR3 probes [n = 217]
total IGH rearrangements	75 [34.6]
t(4;14)(p16;q32)	25 [11.5]
monosomy 4 or 4p16 deletion	4 [1.9]
monosomy 14 or 14q32 deletion	12 [5.2]
IGHv loss	17 [12.8]
4p16 gain	23 [10.9]
14q32 gain	8 [3.4]

Abbreviations: CDKN2C Cyclin-Dependent Kinase Inhibitor 2C, CEP17 Chromosome 17 centromere, CKS1B Cyclin-Dependent Kinases Regulatory Subunit 1, FAF1 FAS-associated Factor 1, FGFR3 Fibroblast Growth Factor Receptor 3, FISH fluorescence in-situ hybridization, IGH Immunoglobulin Heavy Locus, IGHv Immunoglobulin Heavy Locus variable region, TP53 Tumour Protein P53

ISSN: 1755-8166