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Fig. 4 | Molecular Cytogenetics

Fig. 4

From: Scattered genomic amplification in dedifferentiated liposarcoma

Fig. 4

Log ratio and B-allele frequency from SNP array profiles of a the first and b the second sample of the DDLS. The log ratio was normalized to a near-triploid karyotype. Thus, log ratio 0.0 represents 3 copies and in the first sample 4 and 2 copies have log ratios 0.2 and −0.2, respectively. The corresponding shifts in allele frequencies (AF) could be exemplified by chromosome arms 1p (2 maternal +2 paternal copies; AF 0.5), most of 1q (2 + 0 copies; AF 0.75), and chromosome 2 (2 + 1 copies; AF 0.6) in the first sample. Both copy number and AF profiles are less distinct in the second sample, presumably due to larger fraction of stromal cells

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