Fig. 3

Rates of transmethylation of human tumor cell lines and normal human fibroblast cell strains. All cells were labeled with 100 μM [³⁵S]-methionine-containing medium (25 μCi/ml) for 24 h. Periodate-oxidized 3-deazaadenosine was added to a concentration of 10 pM and the accumulation of [³⁵S] AdoHcy was measured at half- hour intervals. Solid lines are human cancer cell lines. Dashed lines are human normal cell strains [38]