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Fig. 1 | Molecular Cytogenetics

Fig. 1

From: Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17)(q32;q11)

Fig. 1

Multiple MYO18A-PDGFRB fusion transcripts in a myeloproliferative neoplasm patient with t(5;17) (q32;q11) (a) The R-banded karyotype showing the translocation t(5;17) (q32;q11). The arrows indicate the structural aberrations of chromosomes 5 and 17; (b) FISH using Vysis LSI PDGFRB Spectrum Green and Orange Probes. A yellow signal denotes a normal PDGFRB gene (5’and 3’regions remain joined), whereas orange and green signals respectively denote the 5’ and 3’ regions of the PDGFRB gene after rearrangement; (c) Bi-directional Sanger sequencing of the PCR product confirms the fusion between MYO18A exon 37(NM_078471.3) and PDGFRB exon 13(NM_002609.3); (d) Four distinct types of MYO18A-PDGFRB fusion transcripts were detected in the patient

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