Table 1 Advantages and unique features of (molecular) cytogenetics compared to other approaches
From: “Classical cytogenetics” is not equal to “banding cytogenetics”
Features of (molecular) cytogenetics |
|---|
1. Analyses on single cell level |
2. Analyses of whole genome |
3. Quick and simple detection of gross genetic alterations |
4. All kinds of structural changes can be detected irrespective if balanced or unbalanced |
5. Analyses ‘in situ’ not ‘in vitro’ |
6. Sex mismatched contamination can be detected easily |
7. Low level mosaics are detectable on routine bases |
8. Monitor cell population stability and heterogeneity by comparing the rates of clonal and non clonal karyotypes |