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Table 1 Advantages and unique features of (molecular) cytogenetics compared to other approaches

From: “Classical cytogenetics” is not equal to “banding cytogenetics”

Features of (molecular) cytogenetics
1. Analyses on single cell level
2. Analyses of whole genome
3. Quick and simple detection of gross genetic alterations
4. All kinds of structural changes can be detected irrespective if balanced or unbalanced
5. Analyses ‘in situ’ not ‘in vitro’
6. Sex mismatched contamination can be detected easily
7. Low level mosaics are detectable on routine bases
8. Monitor cell population stability and heterogeneity by comparing the rates of clonal and non clonal karyotypes