Skip to main content

Table 3 Summary of the follow up results of embryos from three PGD cycles performed for couple A with a male karyotype 46,X,t(Y;4)(q12;p15.32)

From: Meiotic outcome in two carriers of Y autosome reciprocal translocations: selective elimination of certain segregants

PGD

cycle no. /

Embryo no.

Follow up method

Day 5–7 Follow up result

(Diagnostic result where follow up result not available)

Meiotic segregation (stage determined)

Chromosomes contributed by carrier parent

Embryo grade on follow up

C1 E2

aCGH

Female embryo with

additional aneuploidies

Alternate

(follow up)

X and 4

cavitating morula

C1 E3

aCGH

Female embryo with multiple chromosome abnormalities

Alternate

(follow up)

X and 4

pre-morula

C1 E4

n/a

Embryo transferred

(normal female embryo)

Alternate

(diagnosis)

X and 4

7 cells 2+

C1 E6

FISH

Male unbalanced for translocation

Adjacent-1

(follow up)

der Y and 4

blastocyst

C1 E9

FISH

Male unbalanced for translocation

Adjacent-1

(follow up)

der Y and 4

degenerating embryo

C1 E10

FISH

Male unbalanced for translocation

Adjacent-1

(follow up)

der Y and 4

hatched blastocyst

C1 E12

FISH

Male unbalanced for translocation

Adjacent-1

(follow up)

der Y and 4

morula

C2 E1

n/a

Embryo transferred

(normal female embryo)

Alternate

(diagnosis)

X and 4

pre-morula

C2 E2

FISH

No result

(Female unbalanced for translocation)

Unknown segregation (diagnosis)

-

blastocyst

C2 E3

FISH

No result

(Male unbalanced for translocation)

3:1

(diagnosis)

der Y

blastocyst

C2 E4

FISH

No result

(Male; mosaic)

Unknown segregation (diagnosis)

-

blastocyst

C3 E1

n/a

Embryo cryopreserved

(aaCGH – Male embryo with no gains or losses detected)

Alternate

(diagnosis)

der Y and der 4

blastocyst

C3 E2

n/a

Embryo cryopreserved

(aaCGH result – normal female embryo with no gains or losses detected)

Alternate

(diagnosis)

X and 4

blastocyst

C3 E3

aCGH

Male embryo unbalanced for the translocation, with

additional aneuploidies

Adjacent-1

(follow up)

der Y and 4

morula

C3 E4

n/a

Embryo transferred

(normal female embryo)

Alternate

(diagnosis)

X and 4

pre-morula

C3 E5

n/a

Embryo cryopreserved- (aaCGH result – normal female embryo with no gains or losses detected)

Alternate

(diagnosis)

X and 4

blastocyst

  1. C PGD cycle no, E Embryo no
  2. aDiagnostic aCGH result using 24Sure + arrays after a re-biopsy at blastocyst stage on day 6 of embryo development