Fig. 1

a Schematic representation of the studied genes by the two panels (MLPA panel ME028 and panel P343) of probes and of breakpoints on chromosome 15. Arrows indicate the genes identified by each panel (P343 – dark arrows; MEO28 – blue arrows), some of the genes (two arrows) are common to both panels; b Schematic representation of the extent of alterations detected in the region 15q11-15q13 by the two MLPA panels and the involved genes in the studied cases, with duplications in green boxes, triplications represented in yellow and deletions in red; c Schematic representation of the alteration detected in the region 22q13.33 by the MLPA P343 panel. BP-break point; C – Case; CEN-centromere; Del-deletion; Dup-duplication; mos-mosaic; TEL-telomere; Trip-triplication