Fig. 7

Cellular morphologies and karyotypes of melanoma IGR-39 (a, b) and of a corresponding metastasis IGR-37 (c, d). The comparisons show once more that the primary melanoma IGR-39 and the corresponding metastasis IGR-37 have similar, but distinct cell morphologies (a, c) and that their karyotypes are closely related but differ in ploidy number (b, d). The primary cancer has a hyper-tetraploid karyotype and the metastasis a closely related, but hyper-triploid karyotype. The relationship is based on chromosome copy numbers that differ from each other by the ploidy factor that sets apart the two karyotypes. The karyotypes also differ from each other in several individual chromosome numbers and in several individual marker chromosomes (see Tables 1 and 2). The cells were propagated and karyotyped as described for Fig. 2 and in the text