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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Inherent variability of cancer-specific aneuploidy generates metastases

Fig. 2

Cellular morphologies and karyotypes of breast cancer HIM-2 (a, b) and of a corresponding brain metastasis HIM-5 (c, d). The comparisons show that the primary cancer HIM-2 and corresponding metastasis HIM-5 have very similar but distinct cell morphologies (a, c) and karyotypes (b, d). Both primary cancer and metastasis have near diploid karyotypes with the same numbers and structures of chromosomes, except for a trisomy 10 that is missing in the metastasis HIM-5 (d). The cells were photographed at 120X in cell culture dishes (Methods). The cells of the primary cancer were found to be more refractive and growing at modestly higher rates than the metastasis. The chromosomes were prepared from metaphase-cells and color-coded as described in Methods

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