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Fig. 13 | Molecular Cytogenetics

Fig. 13

From: Inherent variability of cancer-specific aneuploidy generates metastases

Fig. 13

a, b, c, d, e Karyotypic evidence that the metastasis SW-620 is an individual subspecies of SW-480 or of an unknown common precursor. The karyotypic theory of metastasis predicts that metastases have individual clonal karyotypes that differ from those of parental cancers in individual metastasis-specific aneusomies. To test this theory we have compared karyotype-arrays of the metastasis SW-620 to that of two clones of the presumed primary SW-480, prepared as described for Fig. 9. Figure 13 a, b, c and the attached table show that 75 - 100% of the chromosomes of SW-620 and 53–100% of the chromosomes of SW-480 C1 and 75-100% of the chromosomes of SW-480 C2 were clonal, and that the two cancer clones and the metastasis formed similar clonal patterns. The karyotype of the metastasis differed from that of the primary cancer SW-480 C1 in 25 of 38 average SW-480 C1 aneusomies and differed from SW-480 C2 in 27 of 38 average aneusomies (Fig. 13a, b , c, d, e and Table 1). The copy numbers of most non-clonal chromosomes including marker chromosomes differed from clonal averages ± 1 (Fig. 13a, b , c and specifically Fig. 13d, e ). The chromosomes with non-clonal copy numbers represent the ongoing karyotypic variation predicted by the inherent variability of cancer-specific aneuploidy (See Fig. 11d, e and Background). We conclude that the metastasis SW-620 is a subspecies of the parental colon cancer SW-480 or of a common unknown precursor

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