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Table 1 Six recurrent chromosomal rearrangements (frequency >15 % in the entire WT group) and microdeletions of WT1 and WTX genes according to the relapse status

From: Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors

WT group Recurrent rearrangements (chromosome arm/focal) Whole-chromosome aneuploidies Microdeletion of known WT genes
1p(−) 1q(+) 7p(−) 7q(+) 11q(−) 16q(−) chr6 chr8 chr12 chr20(+) chr22(−) WT1 WTX (AMER1)
No-relapse (n = 31) 5 11 7 6 7 6 7 6 5 5 2 2 2
frequency 16.1 % 35.5 % 22.6 % 19.3 % 22.6 % 19.3 %       6.4 % 6.4 %
Relapse (n = 19) 3 12 4 5 6 6 3 3 4 2 1 4 1
frequency 15.8 % 63.2 %a 21.0 % 26.3 % 31.6 % 31.6 %       21.0 %a 5.3 %
  1. aSignificant differences between WTs derived from patients who later relapsed or not