Table 1 Six recurrent chromosomal rearrangements (frequency >15Â % in the entire WT group) and microdeletions of WT1 and WTX genes according to the relapse status
From: Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors
WT group | Recurrent rearrangements (chromosome arm/focal) | Whole-chromosome aneuploidies | Microdeletion of known WT genes | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1p(−) | 1q(+) | 7p(−) | 7q(+) | 11q(−) | 16q(−) | chr6 | chr8 | chr12 | chr20(+) | chr22(−) | WT1 | WTX (AMER1) | |
No-relapse (n = 31) | 5 | 11 | 7 | 6 | 7 | 6 | 7 | 6 | 5 | 5 | 2 | 2 | 2 |
frequency | 16.1Â % | 35.5Â % | 22.6Â % | 19.3Â % | 22.6Â % | 19.3Â % | Â | Â | Â | Â | Â | 6.4Â % | 6.4Â % |
Relapse (n = 19) | 3 | 12 | 4 | 5 | 6 | 6 | 3 | 3 | 4 | 2 | 1 | 4 | 1 |
frequency | 15.8 % | 63.2 %a | 21.0 % | 26.3 % | 31.6 % | 31.6 % |  |  |  |  |  | 21.0 %a | 5.3 % |