Fig. 3

Genomic deletions detected in Wilms tumours. a Genomic array-CGH profile of one Wilms tumour (WT329) showing the heterozygous loss detected at 6q16.3q21 (red box). b In the chromosome 6 ideogram, the red bar marks a 1.6 Mb microdeletion, and underneath is the array-CGH profile of the region. c DNA copy number evaluation of the HACE1 by qPCR; the red bar represents the tumour sample and the white bar represents the control. Each bar represents the average copy number of 3 replicates, and the error bars show the standard deviation (adapted from CopyCaller software, Applied Biosystems). The results show the presence of a single copy of the HACE1 sequence in the tumour genome compared to controls. d Genomic array-CGH profile of one Wilms tumour (WT201) showing the homozygous deletion detected at 11p13p12 (red box). e In the chromosome 11 ideogram, the red bar marks an 825 kb homozygous deletion, and underneath is the array-CGH profile of the region. f DNA copy number evaluation of the BBOX by qPCR; the red bars represent the tumours samples and the white bar represents the control. Each bar represents the average copy number of 3 replicates, and the error bars show the standard deviation (adapted from CopyCaller software, Applied Biosystems)