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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors

Fig. 2

Genomic amplifications detected in one Wilms Tumour. a Genomic array-CGH profile of one Wilms tumor (WT1104) showing amplifications located in 1p and 2q (red boxes). b In the chromosome 1 ideogram, the blue box marks a 2.4 Mb 1p31.1 amplification containing only one coding gene, LPHN2, and underneath is the array-CGH profile of the genomic region. c DNA copy number evaluation of the LPHN2 by qPCR; the blue bar represents the tumor sample and the white bar the control. Each bar represents the average copy number of 3 replicates, and the error bars show the standard deviation (adapted from CopyCaller software, Applied Biosystems). d In the chromosome ideogram, the blue box marks a 300 kb amplification at 2q24.1, and underneath is the array-CGH profile of the genomic region. e DNA copy number evaluation of the UPP2 by qPCR; the blue bars represent three tumor samples and the white bar represents the control. Each bar represents the average copy number of 3 replicates, and the error bars show the standard deviation (adapted from CopyCaller software, Applied Biosystems)

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