| MLPA | MS-MLPA | I-FISH result | SNP array result | Treatment | |||
---|---|---|---|---|---|---|---|---|
Gene | Location | Result | Gene | Result | Â | Â | Â | |
First resection - geminocystal astrocytoma | IDH1 | 2q33.3 | R132H | MSH2 | normal | deletion of 19q amplification of 13q | 3p26.3p11.1(4,367,515-90,526,515)x1, 3q28q29(195,706,944-195,724,476)x1, 7p22.3p14.1(141,332-43,215,151)x2hmz, 12q12qq22(40,031,350-93,333,050)x1, 12q23.1q23.2(109,796,312-111,857,062)x1, 13q14.3(51,016,936-54,208,554)x1, 13q21.33q34(68,955,942-115,106,996)x3, 19q13.2q13.43(41,004,075-58,610,254)x1 | NO |
CRBN | 3p26.3 | del | ||||||
CRELD1 | 3p25.3 | del | ||||||
VHL | 3p25.3 | del | MSH6 | normal | ||||
PPARG | 3p25.1 | del | ||||||
RAF1 | 3p25.1 | del | ||||||
HESX1 | 3p14.3 | del | MLH1 | normal | ||||
LFNG | 7p22.2 | normal | ||||||
FKBP9 | 7p14.3 | normal | ||||||
GLI3 | 7p14.1 | normal | MSH3 | normal | ||||
ADAM22 | 7q21.12 | normal | ||||||
TFR2 | 7q22.1 | normal | ||||||
KIAA1549 | 7q34 | normal | PMS2 | normal | ||||
HIPK2 | 7q34 | normal | ||||||
MKRN1 | 7q34 | normal | ||||||
BRAF | 7q34 | normal | MGMT | normal | ||||
DPP6 | 7q36.2 | normal | ||||||
MIR31 | 9p21.3 | normal | ||||||
CDKN2A | 9p21.3 | normal | MLH3 | normal | ||||
CDKN2B | 9p21.3 | normal | ||||||
IDH2 | 15q26.1 | normal | ||||||
Second resection - diffuse astrocytoma | IDH1 | 2q33.3 | R132H | MSH2 | normal | deletion of 19q amplification of 13q | 3p26.3p11.1(4,367,515-90,526,515)x1, 3q28q29(195,706,944-195,724,476)x1, 7p22.3p14.1(141,332-43,215,151) x2hmz, 9q34.11q34.3(131,306,847-138,275,572)x3, 10p15.3(135,708-1,639,362)x3, 12q12qq22(40,031,350-93,333,050)x1, 12q23.1q23.2(109,796,312-111,857,062)x1, 13q14.3(51,016,936-54,208,554)x1, 13q21.2q21.3 (61,757,866-62,558,596)x3, 13q21.31(62,603,583-62,702,893)x1, 13q21.31q21.33 (63,341,681-70,114,200)x1, 13q21.33q34 (68,955,942-115,106,996)x3, 19q13.2q13.43(41,004,075-58,610,254)x1 | NO |
CRBN | 3p26.3 | del | ||||||
CRELD1 | 3p25.3 | del | ||||||
VHL | 3p25.3 | del | MSH6 | normal | ||||
PPARG | 3p25.1 | del | ||||||
RAF1 | 3p25.1 | del | ||||||
HESX1 | 3p14.3 | del | MLH1 | normal | ||||
LFNG | 7p22.2 | normal | ||||||
FKBP9 | 7p14.3 | normal | ||||||
GLI3 | 7p14.1 | normal | MSH3 | normal | ||||
ADAM22 | 7q21.12 | normal | ||||||
TFR2 | 7q22.1 | normal | ||||||
KIAA1549 | 7q34 | normal | PMS2 | normal | ||||
HIPK2 | 7q34 | normal | ||||||
MKRN1 | 7q34 | normal | ||||||
BRAF | 7q34 | normal | MGMT | methylated (51Â %) | ||||
DPP6 | 7q36.2 | normal | ||||||
MIR31 | 9p21.3 | normal | ||||||
CDKN2A | 9p21.3 | normal | MLH3 | normal | ||||
CDKN2B | 9p21.3 | normal | ||||||
IDH2 | 15q26.1 | normal | ||||||
Third resection - anaplastic astrocytoma | IDH1 | 2q33.3 | R132H | MSH2 | normal | deletion of 19q amplification of 13q trisomy 7 | 3p26.3p11.1(4,367,515-90,526,515)x1, 3q28q29(195,706,944-195,724,476)x1, 7p22.3p14.1(141,332-43,215,151) x2hmz, 8q11.1q22.3 (48,043,253-106,052,343)x1, 9q34.11q34.3(131,306,847-138,275,572)x3, 10p15.3 (135,708-1,639,362)x3, 10q22.3q23.1(81,643,451-84,775,286)x1, 12q12qq22 (40,031,350-93,333,050)x1, 12q23.1q23.2(109,796,312-111,857,062)x1, 13q14.3 (51,016,936-54,208,554)x1, 13q21.2q21.3 (61,757,866-62,558,596)x3, 13q21.31 (62,603,583-62,702,893)x1, 13q21.31q21.33(63,341,681-70,114,200)x1, 13q21.33q34(68,955,942-115,106,996)x3, 19q13.2q13.43(41,004,075-58,610,254)x1 | Chemotherapy |
CRBN | 3p26.3 | del | ||||||
CRELD1 | 3p25.3 | del | ||||||
VHL | 3p25.3 | del | MSH6 | normal | ||||
PPARG | 3p25.1 | del | ||||||
RAF1 | 3p25.1 | del | ||||||
HESX1 | 3p14.3 | del | MLH1 | normal | ||||
LFNG | 7p22.2 | normal | ||||||
FKBP9 | 7p14.3 | normal | ||||||
GLI3 | 7p14.1 | normal | MSH3 | normal | ||||
ADAM22 | 7q21.12 | normal | ||||||
TFR2 | 7q22.1 | normal | ||||||
KIAA1549 | 7q34 | normal | PMS2 | normal | ||||
HIPK2 | 7q34 | normal | ||||||
MKRN1 | 7q34 | normal | ||||||
BRAF | 7q34 | normal | MGMT | methylated (51Â %) | ||||
DPP6 | 7q36.2 | normal | ||||||
MIR31 | 9p21.3 | normal | ||||||
CDKN2A | 9p21.3 | normal | MLH3 | normal | ||||
CDKN2B | 9p21.3 | normal | ||||||
IDH2 | 15q26.1 | normal |