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Table 3 Short description on ancestral SRGAP2 function

From: Complex intrachromosomal rearrangement in 1q leading to 1q32.2 microdeletion: a potential role of SRGAP2 in the gyrification of cerebral cortex

Gene mRNA expression Protein expression Function Knockout Knockdown Overexpression
SRGAP2a ↑ Proliferative zone (VZ and SVZ)
↑ Postmitotic regions (CP)
↑ throughout cortical development culminating at P1 corresponding to the peak of neuronal migration in the cortex
negatively regulate the rate of radial migration by promoting LP branching and dynamics
stage 1 neurons:
through its F-BAR domain, induces filopodia
stage 2 neurons:
↑ significantly increased the total number of primary neurites emerging from the cell body
↑ increase the number of primary neurite branches
mice are viable (although born significantly below the expected Mendelian ratio)
No abnormality in cortical lamination
dendritic spine morphology:
↑ neck length
↑ spine density
Juvenile: ↓ head width
Adult: ↑ head width
↓ in cortical neurons led to a significant decrease in both axonal and dendritic branching
↑significant increase in the percentage of neurons that have reached the dense CP and a corresponding decreased percentage of neurons in the IZ
↑ accelerated radial migration
↓ LP in layer 5/6 was significantly less branched and less complex
dendritic spine morphology:
↑ neck length
↑ spine density
Juvenile: ↓ head width
Adult: ↑ head width
significantly reduced the number of cells reaching the CP
↓severely inhibited radial migration
↑increase in the percentage of neurons with multiple processes emerging from the cell body – induce excessive branching of radially migrating neurons
no transition from multipolar cells to a full LP (no cell body translocation)
↑ spine heads
↓ spine neck
↑ enlargement of dendritic spines
  1. VZ ventricular zone
  2. SVZ subventricular zone
  3. CP cortical plate
  4. LP leading process
  5. IZ intermediate zone
  6. aFunction of ancestral SRGAP2