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Fig. 5 | Molecular Cytogenetics

Fig. 5

From: Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia

Fig. 5

Single Nucleotide Polymorphism (SNP) array analysis. a Confirmation of an extra copy of chromosome 12. In the Log R ratio panel (left) chromosomal boundaries between the q terminal of chromosome 11, chromosome 12, and the p terminal of chromosome 13 are demarcated by lines. The expanded chromosome 12 view (right), shows an isolated view of chromosome 12 (B-Allele frequency). b Microduplication of the genomic region containing ERCC2 gene. c Genomic mapping of ERCC2 gene located in the 19q13.32 cytogenetic band, proximal to the BCL3 gene locus (19q13.31). d Placement of the ERCC2 gene relative to the hypothesized IGH;BCL3 rearrangement junction depicted in the schematics (the possibility exists that ERCC2 duplication occurred on the non-translocated chromosome 19 as stated in text)

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Molecular Cytogenetics

ISSN: 1755-8166