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Fig. 3 | Molecular Cytogenetics

Fig. 3

From: Copy number changes and methylation patterns in an isodicentric and a ring chromosome of 15q11-q13: report of two cases and review of literature

Fig. 3

Mechanisms for the idic(15) and ring 15. a. A schematic drawing shows the U-type exchange during meiosis for the formation of the idic(15) with a BP3::BP3 fusion. b. A schematic drawing shows the two-step process for the formation of r(15) from the initial ring formation with break-fusion at BP5, the formation of double ring through replication, and subsequent asymmetric breakage-fusion for segmental duplication and deletion (thin line for breakpoint, dash line for joining point)

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