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Fig. 3 | Molecular Cytogenetics

Fig. 3

From: 3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances

Fig. 3

CCK interctome (protein interaction network). Using irregular geometric shapes/cartoons, interctome parts related to different pathways and/or molecular functions are depicted: Ca2+-calcium metabolism; Ca2+ and Zn2+-(pro-)insulin-zinc-calcium complexes; cholecystokinins-interactome part related to cholecystokinin receptor pathway (i.e. CCK-regulated food intake); metalloproteases (carboxypeptidase)-interactome part related to the pathway of biosynthesis of peptide hormones and neurotransmitters (including insulin) being a likely link between CCK-regulated food intake pathways and zinc metabolism; metalloproteases (Zn2+ binding)-interactome parts related to MEP1A- and MEP1B-mediated zinc ion binding, which interact with CCK. The interactome was processed by Cytoscape software (Version: 3.1.1) [48]

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Molecular Cytogenetics

ISSN: 1755-8166