Fig. 15
From: Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells
Distinct cell morphologies of four Individual focal colonies from SV40-infected mouse embryo cells. To test the theory that individual karyotypes encode neoplastic clones with individual phenotypes, we analyzed the cellular morphologies of four focal colonies that arose from SV40-infected mouse embryo cells. As seen by 125-fold magnification of cultures of four such colonies, F1 (a), F9 (b), F10 (c) and F11 (d), each clone had an individual and apparently clonal cell morphology. This result indicates that individual genotypes, rather than common SV40 genes encode the morphologies of these virus-induced colonies