Fig. 12

Karyotype arrays of six morphologically distinct focal colonies from SV40-infected rat lung cells: second pair of three. To test the theory that individual clonal karyotypes encode the individual phenotypes, two more of the six morphologically distinct rat clones described in Fig. 10 were compared. a shows that F3 has a near-diploid karyotype of 41 chromosomes that were 70–100 % clonal. Accordingly, the F3 chromosomes formed an individual, quasi-clonal karyotype array, which was different from those of F8 and F33 shown in Fig. 11. A third of the F3 cells had near-tetraploid karyotypes that appeared to be duplications of the predominant near-diploid F3 karyotypes. b shows that F100 has a near-diploid karyotype with 43 chromosomes that were 95–100 % clonal. Accordingly the F100 chromosomes also formed a quasi-clonal F100 karyotype array, which was different from those of F3, F8 and F33. Thus the karyotypes of four distinct neoplastic rat clones support the theory that individual karyotypes encode the individual phenotypes of neoplastic clones