Fig. 10
From: Karyotype alteration generates the neoplastic phenotypes of SV40-infected human and rodent cells
Individual cell morphologies of six focal colonies from cultured primary rat lung cells, three weeks after infection with SV40. To test the theory that the karyotypes of individual neoplastic clones encode individual phenotypes, we analyzed the cellular morphologies of six focal colonies from SV40-infected rat lung cells (see example in Fig. 9). As can be seen by the 120X magnification of cultures of the six focal colonies, F8 (a), F33 (b), F3 (c), F100 (d), F10 (e) and FC1 (f), all clones had individual cell morphologies. This result indicates that individual karyotypes, rather than common viral genes, encode the individual phenotypes of the distinct neoplastic clones