All patients (N = 160) | EGFR FISH negative (N = 128) | EGFR FISH positive (N = 32) | P value | |
---|---|---|---|---|
Age (mean,SD) | 64.02 (9.49) | 64.15 (9.64) | 63.49 (8.99) | 0.725 |
Gender: | ||||
Male | 133 (83.1 %) | 10.7 (80.5 %) | 26 (19.5 %) | 0.752 |
Female | 27 (16.9 %) | 21 (77.8 %) | 6 (22.2 %) | |
Histology: | ||||
Adenocarcinoma | 118 (73.8 %) | 94 (79.7 %) | 24 (20.3 %) | 0.909 |
Squamous cell carcinoma | 41 (25.6 %) | 33 (80.5 %) | 8 (19.5 %) | |
Undifferentiated carcinoma | 1 (0.6 %) | 1 (0.6 %) | 0 (0.0 %) | |
Disease site: | ||||
Oesophagus | 124 (77.5 %) | 100 (80.6 %) | 24 (19.4 %) | 0.422 |
Type I junctional | 16 (10.0 %) | 14 (87.5 %) | 2 (12.5 %) | |
Type II junctional | 20 (12.5 %) | 14 (70.0 %) | 6 (30.0 %) | |
WHO PS: | ||||
0 (Asymptomatic) | 35 (21.9 %) | 32 (91.4 %) | 3 (8.6 %) | 0.085 |
1 (Symptomatic but ambulatory) | 91 (56.9 %) | 72 (79.1 %) | 19 (20.9 %) | |
2 (Symptomatic but resting <50 % of day) | 34 (21.3 %) | 24 (70.6 %) | 10 (29.4 %) | |
Body Mass Index category: | ||||
Underweight | 15 (9.4 %) | 13 (86.3 %) | 2 (13.3 %) | 0.737 |
Normal | 83 (51.9 %) | 66 (76.5 %) | 17 (20.5 %) | |
Overweight | 37 (23.1 %) | 28 (75.7 %) | 9 (24.3 %) | |
Obese | 17 (10.6 %) | 15 (88.2 %) | 2 (11.5 %) | |
Missing data | 8 (5.0 %) | |||
Brain metastases | ||||
No | 158 (98.8 %) | 127 (80.4 %) | 31 (19.6 %) | 0.361 |
Yes | 2 (1.3 %) | 1 (50.0 %) | 1 (50.0 %) | |
No. of previous chemotherapies: | ||||
1 | 103 (64.4 %) | 83 (80.6 %) | 20 (19.4 %) | 0.406 |
2 | 50 (31.1 %) | 38 (76.0 %) | 12 (24.0 %) | |
3 | 7 (4.4 %) | 7 (100.0 %) | 0 (0.0 %) |