Skip to main content

Table 3 Association of EGFR FISH status with clinicopathological features

From: Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

 

All patients (N = 160)

EGFR FISH negative (N = 128)

EGFR FISH positive (N = 32)

P value

Age (mean,SD)

64.02 (9.49)

64.15 (9.64)

63.49 (8.99)

0.725

Gender:

    

 Male

133 (83.1 %)

10.7 (80.5 %)

26 (19.5 %)

0.752

 Female

27 (16.9 %)

21 (77.8 %)

6 (22.2 %)

 

Histology:

    

 Adenocarcinoma

118 (73.8 %)

94 (79.7 %)

24 (20.3 %)

0.909

 Squamous cell carcinoma

41 (25.6 %)

33 (80.5 %)

8 (19.5 %)

 

 Undifferentiated carcinoma

1 (0.6 %)

1 (0.6 %)

0 (0.0 %)

 

Disease site:

    

 Oesophagus

124 (77.5 %)

100 (80.6 %)

24 (19.4 %)

0.422

 Type I junctional

16 (10.0 %)

14 (87.5 %)

2 (12.5 %)

 

 Type II junctional

20 (12.5 %)

14 (70.0 %)

6 (30.0 %)

 

WHO PS:

    

 0 (Asymptomatic)

35 (21.9 %)

32 (91.4 %)

3 (8.6 %)

0.085

 1 (Symptomatic but ambulatory)

91 (56.9 %)

72 (79.1 %)

19 (20.9 %)

 

 2 (Symptomatic but resting <50 % of day)

34 (21.3 %)

24 (70.6 %)

10 (29.4 %)

 

Body Mass Index category:

    

 Underweight

15 (9.4 %)

13 (86.3 %)

2 (13.3 %)

0.737

 Normal

83 (51.9 %)

66 (76.5 %)

17 (20.5 %)

 

 Overweight

37 (23.1 %)

28 (75.7 %)

9 (24.3 %)

 

 Obese

17 (10.6 %)

15 (88.2 %)

2 (11.5 %)

 

 Missing data

8 (5.0 %)

   

Brain metastases

    

 No

158 (98.8 %)

127 (80.4 %)

31 (19.6 %)

0.361

 Yes

2 (1.3 %)

1 (50.0 %)

1 (50.0 %)

 

No. of previous chemotherapies:

    

 1

103 (64.4 %)

83 (80.6 %)

20 (19.4 %)

0.406

 2

50 (31.1 %)

38 (76.0 %)

12 (24.0 %)

 

 3

7 (4.4 %)

7 (100.0 %)

0 (0.0 %)

 
  1. Abbreviations: WHO PS World Health Organisation Performance Status