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Fig. 2 | Molecular Cytogenetics

Fig. 2

From: Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

Fig. 2

Kaplan-Meier survival analysis of patients with advanced oesophageal cancer stratified according to EGFR FISH classification performed in 79 patients with advanced oesophageal cancer who were receiving best supportive care. There was a non-significant trend towards poorer overall survival (OS) in patients with EGFR copy number gain (≥4 EGFR copies in ≥40 % cells) compared to those with no EGFR copy number gain; HR 1.55, 95 % CI 0.85 to 2.85, median OS 3.30 v 3.03 months p = 0.15. Kaplan-Meier survival analysis in this patient group demonstrated poorer OS in patients with EGFR amplification compared to EGFR non-amplified cases; HR 2.64, 95 % CI 1.04 to 6.71, median OS 1.76 v 3.17 months, p = 0.03

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Molecular Cytogenetics

ISSN: 1755-8166