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Table 1 Summary of clinical data

From: Double inv(3)(q21q26.2) in acute myeloid leukemia is resulted from an acquired copy neutral loss of heterozygosity of chromosome 3q and associated with disease progression

Case no. Patient 1 Patient 2 Patient 3
Age 72 64 56
Gender Male Female Female
Initial referring diagnosis MDS-RAEB-2 for <1 month CMML <3 months Pancytopenia/thrombocytopenia for one week
Final diagnosis at disease progression AML AMML AML
WBC (× 109/L) 2.4 8.9 1.6
Hb (g/dL) 8.5 11.8 8.2
Platelets (× 109/L) 110 242 41
MCV (fl) 109 112 99
Neutrophil percent (%) 45 44 5.6
Lymphocyte percent (%) 50 22 90.8
Monocyte percent (%) 4 33 1.8
BM blasts % 28 23 54
Follow up (months) 4 3 3.5
Treatment ara-C, imatinib vorinostat decitabine idarubicin, cytarabin
Complete Remission (CR) no no morphological
Stem cell transplant no no no
Overall survival (months) 23 12 5