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Table 1 Baseline characteristics of BCP-ALL with and without chromosome 21 CNAs

From: Evaluation of multiplex ligation dependent probe amplification (MLPA) for identification of acute lymphoblastic leukemia with an intrachromosomal amplification of chromosome 21 (iAMP21) in a Brazilian population

Characteristics MLPA negative MLPA positive P-value
n (%) n (%)
Total 294 (80.0) 74 (20.0)  
Gender    
Male 169 (57.0) 42 (56.8)  
Female 125 (43.0) 32 (43.2) 0.999
Age range, (years)    
≤1 15 (5.1) 0 (0.0)  
2-10 185 (62.6) 62 (83.8)  
>10 94 (32.3) 12 (16.2) 0.001**
Skin color    
White 117 (42.5) 36 (50.0)  
Non-white 159 (57.5) 36 (50.0) 0.300
WBC, x109/l    
Median 61.1 44.8  
Range 0.6-978.0 2.2-95.0  
≤20 153 (52.8) 40 (54.8)  
20-50 56 (19.3) 15 (20.5)  
>50 81 (27.9) 18 (24.7) 0.816
Immunophenotype    
Pro-B ALL 31 (10.5) 1 (1.4)  
Common-ALL 205 (69.8) 58 (78.3)  
Pre-B ALL 58 (19.7) 15 (20.3) 0.038*
NCI risk group    
Standard risk 141 (48.3) 46 (63.0)  
High risk 151 (51.7) 27 (37.0) 0.018*
Status    
Alive 28 (65.1) 21 (75.0)  
Dead 15 (34.9) 7 (25.0) 0.379
  1. n number, WBC white blood cell count x109/l
  2. *p < 0.05; **p ≤ 0.01