Figure 1

Karyotype and FISH analysis. (a) Karyotype of Patient 1. illustrates the supernumerary chromosome 15. (b) FISH analysis of Patient 1. by using probes for UBE3A locus (red) at 15q11q13, D15Z1/CEP15 locus (cyan) at 15p11.2 and PML locus (green) at 15q22 illustrates the tetrasomy of chromosome 15q11q13. (c) Karyotype of Patient 2. illustrates the supernumerary chromosome 15. (d) FISH analysis of Patient 2. by using probes for UBE3A locus (red) at 15q11q13, D15Z1/CEP15 locus (cyan) at 15p11.2 and PML locus (green) at 15q22 illustrates the tetrasomy of chromosome 15q11q13