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Figure 4 | Molecular Cytogenetics

Figure 4

From: A novel acquired inv(2)(p23.3q24.3) with concurrent submicroscopic deletions at 2p23.3, 2p22.1, 2q24.3 and 1p13.2 in a patient with chronic thrombocytopenia and anemia

Figure 4

FISH analyses for validation of array findings and a model of the complex chromosomal inversion of chromosome 2. Partial karyograms of chromosome pair 1 (Panel A) and chromosome pair 2 (Panel B) with the aberrant chromosomes to the left showing FISH results after hybridization using the respective probes as indicated at the top. The relative positions of the directly labeled RP11-based BAC probes are indicated in Figure 3. Panel C. Schematic representation of the inversion on chromosome 2 with breakage points indicated by arrows, together with regions that are deleted and joined. Names of the deleted RP-11-based BAC probes are indicated in red, the moved RP11-730G3 probe is marked by filled green circles, and the RP11-937M17 is indicated by filled red circles. CAP: chromosome arms-specific painting probes; WCP: whole chromosome painting probes.

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