In silico molecular cytogenetics (flow chart of the approach). Molecular cytogenetic data (genome data) acquired through techniques for whole-genome scan (i.e. array CGH) and detecting SGV (i.e. interphase FISH) is analyzed by the bioinformatic approach (genome, epigenome, interactome and metabolome or “reactome” analysis), which is able not only to define interplay between mosaicism, CIN and GIN with heritable/de novo (non-mosaic) genomic variations, but also to identify candidate disease processes allowing appropriate genotype-phenotype correlations and, thereby, determination of intrinsic disease mechanisms. The latter has the potential to become a basis for successful personalized molecular therapy (scheme was partially inspired by ,,).