Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study

Table 7 Comparison of frequencies of major gains and losses of genomic regions from this study and previous reports

Method	Etiology	Chromosomal gain (frequency, %)								Chromosomal loss (frequency, %)						References
Method	Etiology	1q	5p	5q	7p	7q	8q	17q	20q	1p	4q	6q	8p	9p	17p	References
Conventional CGH	HCV, HBV, or non-viral	46	27	<5	<5	<5	69	46	31	35	42	15	58	27	31	[12]
BAC or Oligo CGH	HCV, HBV, or non-viral	>25	NA*	NA	NA	NA	>25	>25	NA	NA	>25	>25	>25	>25	>25	[11]
Conventional CGH	HCV, HBV, or non-viral	49	<5	6	13	15	55	13	12	18	33	33	55	13	22	[13]
Conventional CGH	HCV or HBV	46	<5	<5	<5	<5	41	37	<5	24	39	61	44	24	<5	[14]
Conventional CGH	HCV only	46	5	5	9	9	31	43	27	37	48	23	28	9	37	[10]
Conventional CGH	HCV only	79	16	11	16	11	37	16	11	32	53	21	32	11	79	[9]
oligo CGH	HCV only	80	33	27	33	40	60	<5	<5	20	33	7	33	20	40	This study