Comprehensive chronic lymphocytic leukemia diagnostics by combined multiplex ligation dependent probe amplification (MLPA) and interphase fluorescence in situ hybridization (iFISH)

Table 6 Samples from Additional file 2: Table S2 are listed according to the groups suggested in Figure 2

Results according to MLPA	Adverse prognosis	Intermediate or unclear prognosis	Good prognosis including groups “favorable” and “unfavorable”	No aberrations
Samples	1, 10, 12, 14, 15, 16, 17, 18, 19, 24, 34, 35, 38, 39, 54, 58, 61, 63, 64, 65,	5, 37, 62, 68	2, 4, 13, 20, 21, 22, 23, 25, 26, 27, 28, 29, 30, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 55, 56*, 66, 67, 69	3, 6, 7, 8, 9, 11, 31, 32, 33, 36, 57, 59, 60, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85
Number of samples per group (absolute)	20	4	32	29
Number of samples per group (percent)	*23.5*	5	*37.5*	34

Samples marked with * have biallelic deletion in 13q14 as substantiated by iFISH or deletion of 13q14.2 and 13q14.3, thus going from favorable to unfavorable subgroup within good prognosis group after iFISH (see Table 7). Figures printed not bold and not in italics are case numbers; figures printed bold and in italics are absolute numbers of samples or same numbers in percent.

ISSN: 1755-8166