Suggestion how to proceed when doing MLPA as a primary test after GTG-banding: in case MLPA finds a tumor marker with adverse prognosis no further iFISH analyses is necessary. In case of an MLPA result suggesting intermediate, unclear or good iFISH for 3 to 6 target regions should be done. A probe for 6q may be also used; however, as case with a del(6q) are rare we would not recommend it at present as really indicated to be applied. According to the obtained results cases need to be regrouped. Finally, iFISH can be used to subclassify cases with good prognosis into such with favorable and unfavorable good prognosis.