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Figure 3 | Molecular Cytogenetics

Figure 3

From: Delineation variable genotype/phenotype correlations of 6q27 terminal deletion derived from dic(6;18)(q27;p10)

Figure 3

Cytogenetical and molecular genetical description of the fetus. A) Cytogenetic analysis revealed a derivative chromosome 6 (blue arrow). B) SNP-Array shows deletion of 1.3 Mb at 6q27 to 6qter and a duplication of 15.2 Mb in the short arm of chromosome 18 (yellow arrow). C) Fluorescence in situ hybridization (FISH) 1) using BAC-probes RP11-614P3 (=6q27-Red), RP11-196G15 (=6p22.3-Orange), RP11-1035E2 (=18p11.32-Green) demonstrated the deletion of 6q27 and the duplication of 18p11.32; 2) using a centromeric probe D18Z1 (=cep18-Green) gave three signal and indicated that the derivative chromosome 6 is dicentric.

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Molecular Cytogenetics

ISSN: 1755-8166