Inter-individual methylation variability in differentially methylated regions between maternal whole blood and first trimester CVS

Table 1 Ranking of DMRs tested according to the difference between mean enrichment values for each DMRs

Marker	Mean WBF	Mean CVS	Mean difference	SD WBF	SD CVS	U pval	Coefficient of variation WBF	Coefficient of variation CVS
EI-4	0.017	6.384	6.367	0.022	2.143	1.53E-17	1.294	0.336
EII-1	0.065	5.319	5.254	0.071	1.937	7.06E-18	1.092	0.364
H2	0.135	4.068	3.933	0.093	1.252	7.06E-18	0.689	0.308
EI-2	0.064	3.894	3.83	0.2	1.338	7.50E-18	3.125	0.344
EI-3	0.116	3.905	3.789	0.312	1.556	1.96E-17	2.690	0.398
B3	0.126	3.86	3.734	0.1	1.268	2.29E-17	0.794	0.328
M27	0.532	4.113	3.581	0.2	1.386	7.06E-18	0.376	0.337
D2	0.317	3.364	3.047	0.179	1.301	7.06E-18	0.565	0.387
M28	0.189	2.777	2.588	0.125	0.919	7.06E-18	0.661	0.331
M1E	0.149	2.636	2.487	0.097	0.742	3.44E-17	0.651	0.281
Id1	0.398	2.682	2.284	0.155	0.932	1.04E-17	0.389	0.348
A5	0.337	2.505	2.168	0.159	0.986	7.06E-18	0.472	0.394
C5	0.18	2.321	2.141	0.106	0.84	7.06E-18	0.589	0.362
C1	0.106	2.229	2.123	0.083	0.635	7.06E-18	0.783	0.285
AII-2	0.065	2.003	1.938	0.084	0.933	1.23E-16	1.292	0.466
On2	0.281	1.993	1.712	0.138	0.552	7.06E-18	0.491	0.277
Nn2	0.245	1.924	1.679	0.107	0.78	7.07E-18	0.437	0.405
J2	0.116	1.707	1.591	0.079	0.519	7.06E-18	0.681	0.304
Fd1	0.135	1.676	1.541	0.101	0.513	7.06E-18	0.748	0.306
M25	1.038	1.822	0.784	0.452	0.655	1.88E-09	0.435	0.359
M20	0.42	0.796	0.376	0.186	0.303	2.37E-10	0.443	0.381
M18	0.097	0.22	0.123	0.07	0.151	6.36E-08	0.722	0.686
HYPER	3.124	3.226	0.102	0.68	0.982	0.951	0.218	0.304
HYPO	0.469	0.508	0.039	0.945	0.948	0.119	2.015	1.866

Despite the statistical significance of all enrichment values (p < 0.01), the four markers (M25, M20, M18, Fd1) that showed the lowest difference were not selected as potential DMRs.

ISSN: 1755-8166