Figure 1
Enrichment profile for all DMRs on 50 WBF and 50 first trimester CVS. Box plots show the distribution of the relative fold enrichment values for WBF (black) and CVS (red) for each DMR. The median value is represented by a horizontal line. The bottom of the box indicates the 25th percentile (lower quartile) and the top the 75th percentile (upper quartile). Whisker lines indicate the outlier boundaries [top: median + 3(75%-25%); bottom: median -3(75%-25%)]. A: 11 of 15 newly characterized DMRs show clear separation of the methylation enrichment values between WBF and CVS despite the methylation variability. Fd1, M18, M20, M25 show overlap between the interquartile values, thus they were not characterized as DMRs. B: Previously validated DMRs used as a comparison standard show clear separation between WBF and CVS. HYPER: hypermethylated marker for both tissues, HYPO: Hypomethylated marker for both tissues.