Figure 9

Karyotype arrays of two related clonal neoplasias RMT-CN 61, which evolved from a non-clonal rat mammary hyperplasia. The two related karyotype arrays shown here on the same plot were prepared from three-dimensionally growing neoplastic foci termed RMT-CN 61, which had evolved from a culture of the non-clonal aneuploid mammary hyperplasia RMT 61 within several months (Table 5). A glance at the two karyotype-arrays of the RMT-CN 61 foci shows two closely related clonal karyotypes, one near-diploid and the other near-tetraploid. The two RMT-CN 61 clones contained quasi-clonal chromosome numbers, which averaged 46 ± 8 and 82 ± 5 per cell, respectively. The copy numbers of their normal chromosomes and their common and individual marker chromosomes were 73-100%-clonal. The individuality of the two sister clones is evident from comparisons of their karyotype arrays with the five individual karyotype arrays of the two rat carcinomas and the three neoplastic rat clones shown in Figures 3, 5, 6, 7 and 8.