Figure 8

Karyotype array of the clonal neoplasia RMT-CN 54, which evolved from a non-clonal rat mammary hyperplasia. This karyotype array of the neoplastic clone RMT-CN 54 was prepared from a three-dimensionally growing colony that had evolved from a culture of the non-clonal aneuploid mammary hyperplasia RMT 54 within several months in culture (Table 4). The karyotype array and the attached table show that the RMT-CN 54 clone contained per cell a quasi-clonal, near-tetraploid average number of 80 ± 2 chromosomes. The data also show that the chromosome copy numbers of the clone were 80-100%-clonal, based on a normal tetraploid karyotype. The individuality of the RMT-CN 54 karyotype array is again evident from comparisons with the karyotype arrays of the carcinomas RMT 47–3 and 37–2 and of the clonal neoplasias RMT-CN 65 and 58 shown in Figures 3, 5, 6 and 7.