Localized, non-random differences in chromatin accessibility between homologous metaphase chromosomes

Table 2 Cell lines and single copy FISH probes used to assess chromatin accessibility

Sample ID: cytogenetics	Probes for tracking homologs
Sample ID: cytogenetics	Cytoband, gene: interval	Status
GM10958: 46,XX, t(1;11) (q31.2;q25) pat	1q43.3, RGS7:IVS4-IVS5 1p36.3, intergenic	DA Equivalent
GM10273: 46,XX, t(11;22)(p13;q12.2) pat	22q13.3, ACR:Ex1-IVS3	DA
GM01921: 47,XY, t(8;14)(q13;q13), inv(9)(p11q13) mat, +21	9q34.3, CACNA1B:Ex29-IVS31 9p24.3, C9orf66:Ex1	DA Equivalent
GM06326: 46, X, t(Y;17) (q11.21;q21) pat	17p12, PMP22:IVS3 & ADORA2B:IVS1 17p12, PMP22:IVS4-Ex5 & ADORA2B:Promoter-Ex1	DA Equivalent
GM10958: 46,XX, t(1;11) (q31.2;q25) pat	11q25, OPCML:IVS1	DA
GM10273: 46,XX, t(11;22) (p13;q12.2) pat	11q25, OPCML:IVS1	DA
II-2: 46,XX.ish del (15) (q11.2q13) (D15S10-,UBE3A-) pat	15q12, SNRPN: Promoter:IVS1 & GABRA5:IVS3 15q13.1, HERC2:IVS12-IVS13	DA DA
III-1: 46,XY.ish del(15) (q11.2q13) (D15S10-,UBE3A-) mat	Same as II-2	DA
III-2: 46,XX.ish del(15) (q11.2q13) (D15S10-,UBE3A-) mat	Same as II-2	DA
L12-1980: 46,XX, t(1;17) (p10;q10)	1q43.3, RGS7:IVS4-IVS5 17p12, PMP22:IVS3 & ADORA2B:IVS1	DA DA
L13-72: 46,XX,9qh+	9q34.3, CACNA1B:Ex29-IVS31	DA
L11-729: 46,XY, t(7;22) (q32;q13.33)	22q13.3, ACR:Ex1-IVS3	DA

Cytogenetic nomenclature for each of the samples is indicated. Parental origins of the rearrangements are indicated when known (mat = maternal, pat = paternal). Cells are from human lymphocytes (L12-1980, L13-72, L11-729) or lymphoblastoid cell lines [GM10958, GM10273, GM01921, GM06326, and family II-1 (mother), III-1 (child), III-2 (child)].

ISSN: 1755-8166