Table 1 Comparison of open chromatin features to single copy genomic regions with and without DA
| Â | Â | Open chromatin features | |||||
|---|---|---|---|---|---|---|---|
SC probe probe location [GRCh37] | Gene interval or cytoband | DNase-OS | FAIR-OS | H3K4me | H3K9Ac | H3K27Ac | H3K4me2 |
chr1:1171789-1175143* | 1p36.3, intergenic | 11592 | 8710 | 544.0 | 168.4 | 115.6 | 120.6 |
chr1:1181574-1185503 | FAM132A:Ex1-IVS1 | 7394 | 9695 | 596.5 | 143.0 | 102.8 | 160.9 |
chr1:1628792-1633615 | CDK11B:IVS6 | 10378 | 14274 | 326.3 | 222.1 | 121.8 | 177.6 |
chr1:1632683-1637407 | CDK11B:IVS6 | 12139 | 12829 | 290.7 | 125.8 | 51.8 | 51.8 |
chr1:240965538-240967390 | RGS7:IVS13-IVS14 | 1420 | 9976 | 200.6 | 74.0 | 12.1 | 29.6 |
chr1:240988582-240990678* | RGS7:IVS4-IVS5 | 2840 | 8999 | 125.3 | 55.3 | 7.4 | 59.2 |
chr4:3242502-3246008 | HTT:Ex67 | 9225 | 15222 | 248.0 | 142.8 | 81.4 | 51.8 |
chr5:1421588-1425427 | SLC6A3:IVS4-IVS5 | 4702 | 8574 | 172.0 | 80.3 | 66.6 | 14.8 |
chr5:9355970-9358454 | SEMA5A:IVS3 | 2827 | 16953 | 235.4 | 103.6 | 36.5 | 29.6 |
chr5:9361501-9365307 | SEMA5A:IVS3 | 12398 | 40009 | 3017.6 | 597.4 | 1993.0 | 1530.2 |
chr5:9371425-9374496 | SEMA5A:IVS3 | 1397 | 18058 | 531.5 | 48.5 | 81.4 | 59.2 |
chr5:11042187-11044508 | CTNND2:IVS16 | 2221 | 15462 | 253.7 | 80.3 | 32.6 | 44.4 |
chr5:11071700-11076039 | CTNND2:IVS16 | 4422 | 19382 | 344.8 | 158.4 | 118.5 | 77.8 |
chr5:11084988-11089067 | CTNND2:IVS15 | 2942 | 16403 | 297.3 | 81.4 | 81.4 | 22.2 |
chr5:68462247-68464721* | CCNB1:Ex1-IVS3 | 31707 | 29162 | 1400.2 | 2378.9 | 1953.4 | 2076.3 |
chr7:73506616-73509661 | L1MK1:IVS14 | 32349 | 30750 | 3473.0 | 4213.1 | 5870.8 | 4186.7 |
chr7:73534615-73536880 | L1MK1:Ex1-IVS3 | 3639 | 9068 | 237.2 | 47.3 | 0 | 22.2 |
chr8:116658428-116661455 | TRPS1:IVS1 | 3738 | 15369 | 650.0 | 224.2 | 78.6 | 396.1 |
chr8:116661938-116665132 | TRPS1:IVS1 | 2031 | 15754 | 316.0 | 112.2 | 59.2 | 57.9 |
chr9:213762-215844* | C9orf66:Ex1 | 10945 | 15191 | 868.4 | 1550.5 | 503.2 | 1667.6 |
chr9:133587757-133589963 | ABL1:Ex1b-IVS1b | 32515 | 25514 | 616.8 | 3043.7 | 2278.6 | 1563.2 |
chr9:133616347-133618188 | ABL1:IVS1b | 1917 | 10733 | 341.9 | 83.6 | 42.0 | 71.1 |
chr9:133733132-133735051 | ABL1:IVS3 | 2859 | 8103 | 188.8 | 50.9 | 74.2 | 37.0 |
chr9:133735369-133737639 | ABL1:IVS3 | 2211 | 11425 | 259.7 | 62.8 | 56.1 | 95.6 |
chr9:133745513-133749828 | ABL1:IVS4-IVS6 | 18884 | 37627 | 4959.4 | 477.6 | 982.4 | 998.7 |
chr9:133759487-133764440 | ABL1:Ex11 | 7053 | 15356 | 322.9 | 174.4 | 142.9 | 74.0 |
chr9:140952206-140954439* | CACNA1B:Ex29-IVS31 | 4956 | 8277 | 302.2 | 88.8 | 33.8 | 51.8 |
chr9:140969092-140971796 | CACNA1B:IVS33-IVS34 | 4127 | 7686 | 151.2 | 69.2 | 44.4 | 37.0 |
chr11:133180187-133182699* | OPCML:IVS1 | 2306 | 11280 | 202.1 | 77.4 | 37.0 | 133.8 |
chr12:11958559-11960434 | ETV6:IVS2 | 2403 | 19900 | 2947.6 | 327.2 | 751.8 | 757.8 |
chr12:11992883-11994726 | ETV6:IVS2 | 2257 | 16709 | 786.4 | 134.8 | 384.3 | 62.9 |
chr12:11992883-11995741 | ETV6:IVS3 | 2988 | 23954 | 887.0 | 206.0 | 453.6 | 232.7 |
chr13:100626271-100630715 | 13q32.3, intergenic | 11678 | 18628 | 216.6 | 76.2 | 65.8 | 23.2 |
chr13:100643221-100648153 | 13q32.3, intergenic | 7452 | 25389 | 687.8 | 115.4 | 83.2 | 221.4 |
chr15:22690247-22693115 | 15q11.2, intergenic | 1705 | 4996 | 347.0 | 85.2 | 47.4 | 29.6 |
chr15:22853681-22855541 | TUBGCP5:IVS11-IVS13 | 1049 | 21106 | 132.0 | 75.4 | 96.9 | 22.2 |
chr15:23864038-23868139 | 15q11.2, intergenic | 4260 | 17789 | 272.4 | 74.0 | 38.6 | 79.6 |
chr15:23883747-23886037 | 15q11.2, intergenic | 1969 | 6908 | 84.0 | 76.3 | 10.5 | 29.6 |
chr15:23886989-23890525 | MAGEL2:Promoter- 3′UTR | 7602 | 12049 | 198.2 | 88.8 | 51.8 | 50.9 |
chr15:25016909-25018586 | 15q11.2, intergenic | 1670 | 5764 | 216.6 | 38.2 | 48.1 | 111.5 |
chr15:25052358-25054037 | 15q11.2, intergenic | 671 | 6051 | 83.8 | 51.9 | 7.4 | 0 |
chr15:25068481-25070727* | SNRPN: Promoter:IVS1 | 1524 | 7291 | 149.1 | 74.4 | 19.3 | 22.2 |
chr15:25199392-25201602 | SNRPN:IVS4 | 6799 | 10253 | 258.1 | 1391.0 | 937.3 | 486.3 |
chr15:25613407-25617676 | UBE3A:IVS7-IVS8 | 2728 | 26796 | 3025.0 | 81.4 | 182.8 | 96.0 |
chr15:27117096-27119866* | GABRA5:IVS3 | 5815 | 8082 | 140.0 | 40.8 | 37.0 | 29.6 |
chr15:28509526-28511337* | HERC2:IVS12-IVS13 | 4580 | 10908 | 854.2 | 313.8 | 728.2 | 465.3 |
chr15:102388168-102389774 | OR4F13P:IVS3-Ex5 | 950 | 8872 | 64.0 | 47.6 | 37.0 | 29.6 |
chr16:15013674-15017156 | 16p13.11, intergenic | 814 | 984 | 248.3 | 51.8 | 62.2 | 53.0 |
chr16:16412325-16415807 | PKD1P1:IVS2-IVS7 | 473 | 268 | 168.0 | 76.8 | 71.4 | 51.8 |
chr16:16452359-16455837 | 16p13.11, intergenic | 418 | 670 | 98.7 | 54.1 | 65.2 | 44.4 |
chr16:16234893-16236784 | ABCC1:IVS30-Ex31 | 4867 | 11513 | 451.2 | 103.6 | 89.3 | 45.6 |
chr16:18440574-18444056 | 16p12.3, intergenic | 110 | 0 | 181.5 | 74.0 | 73.4 | 31.2 |
chr16:18484058-18487536 | 16p12.3, intergenic | 616 | 907 | 167.7 | 89.9 | 51.8 | 19.1 |
chr17:905599-910582 | ABR:IVS21-3′UTR | 10824 | 19481 | 304.9 | 174.9 | 132.8 | 2.9 |
chr17:941273-943865 | ABR:IVS16 | 3508 | 6315 | 170.9 | 89.1 | 74.0 | 71.8 |
chr17:2591614-2594572 | CLUH:IVS25-3′UTR | 10756 | 11515 | 576.5 | 96.2 | 384.9 | 163.2 |
chr17:2596810-2599164 | CLUH:IVS13-IVS19 | 5323 | 6551 | 301.9 | 112.5 | 63.3 | 37.0 |
chr17:2603297-2606091 | CLUH:IVS3-IVS9 | 7600 | 7093 | 222.1 | 57.0 | 51.8 | 123.2 |
chr17:18128679-18133300 | LLGL1:Promoter-Ex2 | 36213 | 27618 | 1016.0 | 647.8 | 219.2 | 743.9 |
chr17:18143933-18146387 | LLGL1:Ex17-IVS22 | 7467 | 8690 | 136.8 | 114.2 | 37.0 | 16.8 |
chr17:15133018-15136902* | PMP22:IVS4-Ex5 | 5482 | 14180 | 207.3 | 113.3 | 60.8 | 34.6 |
chr17:15150757-15153084* | PMP22:IVS3 | 4694 | 12616 | 321.0 | 77.7 | 28.7 | 44.4 |
chr17:15174803-15176657 | 17p12, intergenic | 2574 | 11 | 163.0 | 89.3 | 37.0 | 31.4 |
chr17:15847751-15849832* | ADORA2B:Promoter-Ex1 | 10751 | 9889 | 763.1 | 241.5 | 79.0 | 980.8 |
chr17:15868752-15870532* | ADORA2B:IVS1 | 2859 | 17457 | 711.4 | 95.0 | 78.8 | 84.7 |
chr17:18150509-18152632 | FLII:IVS15-Ex21 | 23767 | 14999 | 2289.9 | 74.7 | 439.4 | 75.6 |
chr17:18153505-18154823 | FLII:IVS12-IVS14 | 3547 | 3937 | 47.1 | 36.7 | 36.8 | 0 |
chr17:19286892-19288934 | MFAP4:IVS3-Ex6 | 3415 | 5897 | 286.5 | 139.3 | 95.8 | 54.8 |
chr17:37861465-37863632 | ERBB2:IVS5-IVS6 | 5114 | 6170 | 296.6 | 90.6 | 78.3 | 84.4 |
chr17:37882684-37886219 | ERBB2:IVS27-Ex31 | 9666 | 16440 | 1561.2 | 617.8 | 331.8 | 836.4 |
chr17:38500482-38504359 | RARA:IVS2 | 17458 | 19211 | 3584.2 | 597.6 | 650.9 | 813.2 |
chr17:38512106-38514271 | RARA: IVS8-Ex9 | 5468 | 6830 | 177.2 | 130.6 | 125.8 | 88.3 |
chr17:38608442-38610468 | IGFBP4:IVS1-IVS3 | 4526 | 10512 | 230.8 | 39.5 | 29.6 | 62.7 |
chr17:38613433-38617530 | IGFBP4:Ex4 | 8748 | 18085 | 557.1 | 155.4 | 88.8 | 74.0 |
chr17:80290070-80293112 | SECTM1:Ex1-IVS1 | 13714 | 13008 | 2005.4 | 294.1 | 202.4 | 1002.5 |
chr20:10642756-10644909 | JAG1:IVS2-IVS3 | 2943 | 15006 | 1104.1 | 118.6 | 49.2 | 225.7 |
chr21:36259933-36264124 | RUNX1:IVS2 | 26119 | 30777 | 1920.4 | 2050.4 | 1478.7 | 2915.8 |
chr21:39454065-39456057 | DSCR4:IVS2 | 2440 | 7032 | 155.4 | 65.3 | 24.6 | 65.9 |
chr21:39463783-39466136 | DSCR4:IVS2 | 2017 | 10359 | 126.5 | 63.2 | 51.8 | 25.6 |
chr21:39473031-39475467 | DSCR4:IVS2 | 2256 | 10103 | 137.4 | 86.9 | 37.0 | 0.2 |
chr22:19338598-19342289 | HIRA:IVS21-IVS24 | 3429 | 12123 | 325.1 | 150.0 | 59.2 | 37.0 |
chr22:23578368-23581572 | BCR:IVS1 | 6792 | 19899 | 2489.1 | 283.0 | 240.2 | 284.8 |
chr22:23604414-23607814 | BCR:IVS4 | 11921 | 14381 | 1989.6 | 425.4 | 621.7 | 362.3 |
chr22:23623055-23625566 | BCR:IVS8 | 21132 | 16241 | 2543.9 | 311.6 | 501.8 | 451.4 |
chr22:51175125-51178674* | ACR:Ex1-IVS3 | 11986 | 12916 | 175.2 | 85.1 | 37.0 | 58.9 |
chrX:592626-595515 | SHOX:IVS2-Ex3 | 7316 | 7254 | 125.9 | 55.3 | 29.6 | 37.0 |
chrX:597816-600430 | SHOX:IVS3 | 6234 | 7821 | 64.0 | 74.0 | 41.5 | 44.4 |
chrX:602538-605057 | SHOX:IVS5 | 4319 | 4191 | 147.9 | 29.6 | 7.0 | 14.8 |
chrX:7891853-7895877 | PNPLA4:Ex1-IVS2 | 19932 | 42372 | 1854.3 | 2340.4 | 2553.7 | 1715.7 |
chrX:8440844-8443508 | Xp22.31, intergenic | 1639 | 12112 | 151.2 | 59.2 | 30.0 | 45.5 |
chrX:8505855-8509075 | KAL1:IVS9-IVS10 | 4319 | 14875 | 147.9 | 106.6 | 14.8 | 44.4 |
chrX:9613498-9617784 | TBL1X:IVS4 | 4522 | 20294 | 429.2 | 164.6 | 115.6 | 133.7 |
chrX:9685383-9689409 | TBL1X:Ex18 | 3938 | 43044 | 336.8 | 101.4 | 65.5 | 90.3 |