Genome analysis using high resolution 180 K oligo-based array CGH analysis. Panel A, upper panel. Chromosome 5 ideogram showing two submicroscopic deletions detected at the long arm of chromosome 5 at 5q31.2 and 5q35.1-q35.2. Lower panel, zoom view of genomic profile at chromosome 5 where the deleted regions on 5q are indicated by red shade. Panel B, upper panel. Chromosome 18 ideogram showing a submicroscopic deletion detected at the long arm of chromosome 18 at 18q12.3-q21.1. Lower panel, zoom view of genomic profile at chromosome 18 where the deleted region on 18q is indicated by red shade. Vertical blue lines in the zoom view indicate log2 ratios +0.24 and +0.60 and red lines indicate log2 ratios +0.24 and +1.0. The X-axis at the bottom indicates chromosomal position. The insert at the top of the genome profile indicates the chromosomal bands in the zoomed region and their relative position. The relative positions of the different FISH probes used for validation are indicated in different colors according to the direct fluorescent label used. The genes located in the minimum deleted regions are listed according to their relative genomic position (centromeric to telomeric orientation), and the asterisk (*) denotes that the genes separated by a slash represent different transcripts from the same transcriptional unit.