Figure 3
From: 3D-FISH analysis reveals chromatid cohesion defect during interphase in Roberts syndrome
Statistical representation of CB2 radial and mutual positions. (A): Distribution of each PH1 (=CB2 probe) radial position of normal cells (black rings) and Roberts cells (blue triangles). The median was calculated both for normal cells (Mrn, black line) and Roberts cells (MrR, blue line). Radial distances are expressed as a proportion of the radius. Mrn = 0.5285 and MrR = 0.6700: Wilcoxon test was significant (alpha = 0.05) with a p value of 0.0018 showing a significant relocation of PH1 territory towards the edge of the nucleus in Roberts cells. (B): Distribution of CB2 mutual position of normal and Roberts cells. The median was calculated both for normal cells (Mmn,black line) and Roberts cells (MmR, blue line). Mutual distances are expressed as a proportion of the diameter. Mmn = 0.4527 and MmR = 0.3813: Wilcoxon test was significant (alpha = 0.05) with a p value of 0.0829 showing a significant rapprochement of homologous PH1 territories in Roberts cells.