Figure 1
From: 3D-FISH analysis reveals chromatid cohesion defect during interphase in Roberts syndrome
Clinical and cytogenetical description of the fetus. (A): Fetus of 18 weeks gestation with multiple congenital anomalies: hypertelorism, micrognathia, tetraphocomelia and oligodactyly. Scale bar = 2 cm (B): C-banded metaphase chromosomes from the affected fetus showing the pathognomonic cytogenetic anomaly in Roberts Syndrome: chromosomes with premature centromere separation: PCS (black arrows) and heterochromatin puffing. Scale bar = 5 μm.