Table 1 Top functional categories, significantly changed (p < 0.05), ‘Ingenuity’ analysis

1

Organismal functions

Healing

2

Cellular movement

cell movement, chemotaxis, homing, intravasation, invasion, migration

3

Cellular growth and proliferation

colony formation, growth, hypertrophy, proliferation

4

Cell to cell signaling and interaction

attachment, recruitment, activation, adhesion, penetration

5

Hair and skin development and function

cell movement, development, migration

6

Cell death

apoptosis, cell death, survival

7

Skeletal and muscular system development and function

adhesion, cell movement, development, differentiation, formation, migration, proliferation

8

Cellular development

developmental process/disorder, differentiation, growth, hypertrophy, tubulogenesis

9

Cell cycle

cell division process, cell stage, G0/G1 phase transition, G1/S phase transition, G2/M phase transition, interphase, mitosis

10

Tumor morphology

growth, invasion, proliferation, regression, size

11

DNA replication, recombination and repair

synthesis, metabolism of DNA

12

Organismal survival

death, survival

13

Immune response

accumulation, cell movement, proliferation

14

Immune and lymphatic system development and function

accumulation, development, differentiation, growth, mitosis, morphology, proliferation, quantity, size

15

Tissue development

accumulation, adhesion, developmental process, formation

16

Embryonic development

differentiation, quantity, tubulogenesis

17

Organismal development

angiogenesis, developmental process, neovascularization, size

18

Gene expression

activation, binding, expression, stabilization, transactivation, transcription