An evaluation of SOX2 and hTERC gene amplifications as screening markers in oral and oropharyngeal squamous cell carcinomas

Table 2 FISH analysis of TERC/SOX2 loci vs. centromere 3 in OSCC patients according to the clinical characterization

Clinical characterization	SOX2/TERC amplifications/polyploidy				Odds ratio (95% confidence interval), p (two-tailed Fisher exact test)
	Normal	Polyploidy only	Amplification and poliploidy	Total abnormal FISH results	Normal vs. total abnormal FISH results	Normal vs. Polyploidy only	Normal vs. amplification with poliploidy
Controls	21	0	1	1	46.77 (5.91-370) 0.00	N/D² (N/D²) 0.00	21.00 (2.56-455) 0.00
OSCC	22	27	22	49	46.77 (5.91-370) 0.00	N/D² (N/D²) 0.00	21.00 (2.56-455) 0.00
Stage: I, II, III	8	7	8	15	1.29 (0.39 – 4.23), 0.78	1.25 (0.41-6.03) 0.76	1.00 (0.25-4.07) 1.00
Stage: IV	14	20	14	34	1.29 (0.39 – 4.23), 0.78	1.25 (0.41-6.03) 0.76	1.00 (0.25-4.07) 1.00
Stage: I, II	4	5	7	12	0.69 (0.17-2.77), 0.76	0.98 (0.18-5,13) 1.00	0.48 (0.09-2.34) 0.49
Stage: III, IV	18	22	15	37	0.69 (0.17-2.77), 0.76	0.98 (0.18-5,13) 1.00	0.48 (0.09-2.34) 0.49
Oropharynx	6	11	10	21	2.00 (0.59-6.93), 0.29	1.83 (0.47-7.46) 0.38	2.22 (0.53-9.52) 0.34
Outside oropharynx¹	16	16	12	28	2.00 (0.59-6.93), 0.29	1.83 (0.47-7.46) 0.38	2.22 (0.53-9.52) 0.34

ISSN: 1755-8166