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Table 2 FISH analysis of TERC/SOX2 loci vs. centromere 3 in OSCC patients according to the clinical characterization

From: An evaluation of SOX2 and hTERC gene amplifications as screening markers in oral and oropharyngeal squamous cell carcinomas

Clinical characterization SOX2/TERC amplifications/polyploidy Odds ratio (95% confidence interval), p (two-tailed Fisher exact test)
  Normal Polyploidy only Amplification and poliploidy Total abnormal FISH results Normal vs. total abnormal FISH results Normal vs. Polyploidy only Normal vs. amplification with poliploidy
Controls 21 0 1 1 46.77 (5.91-370) 0.00 N/D2 (N/D2) 0.00 21.00 (2.56-455) 0.00
OSCC 22 27 22 49
Stage: I, II, III 8 7 8 15 1.29 (0.39 – 4.23), 0.78 1.25 (0.41-6.03) 0.76 1.00 (0.25-4.07) 1.00
Stage: IV 14 20 14 34
Stage: I, II 4 5 7 12 0.69 (0.17-2.77), 0.76 0.98 (0.18-5,13) 1.00 0.48 (0.09-2.34) 0.49
Stage: III, IV 18 22 15 37
Oropharynx 6 11 10 21 2.00 (0.59-6.93), 0.29 1.83 (0.47-7.46) 0.38 2.22 (0.53-9.52) 0.34
Outside oropharynx1 16 16 12 28
  1. 1Listed in Table 1.
  2. 2Not determined.